What is the difference between ace inhibitors and calcium channel blockers

Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. A single copy of these materials may be reprinted for noncommercial personal use only. This content does not have an English version. This content does not have an Arabic version.

See more conditions. Calcium channel blockers. Products and services. Calcium channel blockers These medications lower blood pressure and treat other conditions such as chest pain and an irregular heartbeat. By Mayo Clinic Staff. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information.

Please try again. Something went wrong on our side, please try again. Show references Mann JFE. Choice of drug therapy in primary essential hypertension. Accessed June 25, Types of blood pressure medications. American Heart Association. Accessed July 26, Sidawy AN, et al.

Atherosclerotic risk factors: Hypertension. Philadelphia, Pa. Accessed July 11, Bakris GL, et al. Accessed July 19, Aronson JK, ed. In: Meyler's Side Effects of Drugs. Amsterdam, Netherlands: Elsevier; Block MJ, et al. Major side effects and safety of calcium channel blockers. See also Medication-free hypertension control 6 surprising signs you may have obstructive sleep apnea After a flood, are food and medicines safe to use?

Alcohol: Does it affect blood pressure? Beta blockers: How do they affect exercise? Blood pressure chart Blood pressure cuff: Does size matter? Blood pressure: Does it have a daily pattern? Blood pressure: Is it affected by cold weather?

BMJ ; : 97 — Australian comparative outcome trial of ACE inhibitor- and diuretic-based treatment of hypertension in the elderly. Clin Exp Hypertens ; 19 : — J Hypertens ; 14 suppl 2 : S41 — S Collins R , MacMahon S : Blood pressure, antihypertensive drug treatment and the risks of stroke and coronary heart disease. Br Med Bull ; 50 : — J Hypertens ; 10 : — A comparison of six antihypertensive agents with placebo.

N Engl J Med ; : — Freis ED : Age and antihypertensive drugs hydrochlorothiazide, bendroflumethiazide, nadolol and captopril. Am J Cardiol ; 61 : — Lancet ; 1 : — J Cardiovasc Pharm ; 10 suppl 7 : S — S J Hypertens ; 17 suppl 2 : S21 — S J Hypertens ; 17 : — Clin Exp Hypertens ; 21 : — Am J Hypertens ; 5 : — Lancet ; i : — Oxford University Press is a department of the University of Oxford.

It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.

Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Address correspondence and reprint request to Prof. Oxford Academic. Adrianne I. Robert Jeffrey MacInnis.

Select Format Select format. Permissions Icon Permissions. Abstract The objective of this study was to determine which of the common groups of antihypertensive drugs is most effective at lowering systolic blood pressure SBP in elderly patients with previously untreated hypertension and the percentage of patients controlled with single or sequential monotherapy.

Table 1 Systolic and diastolic blood pressure mm Hg on the high and low dose of each drug. Low Dose. High Dose. Placebo Sys 66 Open in new tab. ACE Inhibitors. Calcium Blockers. Table 2 Systolic and diastolic blood pressure and pulse rate achieved with each class of drug. Placebo 58 Table 4 Effect of the different drugs on variables that might alter with the various drugs. Paired t test. Open in new tab Download slide. Decrease in systolic blood pressure SBP compared with placebo on the higher dose of each drug.

Systolic blood pressure, arterial rigidity and risk of stroke: the Framingham Study. Google Scholar Crossref. Search ADS. Blood pressure, antihypertensive drug treatment and the risks of stroke and coronary heart disease. Google Scholar PubMed. Antihypertensive efficacy and side effects of three beta-blockers and a diuretic in elderly hypertensive: A report from the STOP-Hypertension study.

Single-drug therapy for hypertension in men. Age and antihypertensive drugs hydrochlorothiazide, bendroflumethiazide, nadolol and captopril. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. The effect of perindopril on blood pressure in humans on different sodium intakes. Management of hypertension: The advent of a new angiotensin II receptor antagonist.

Comparison and interaction of low dose felodipine ER and enalapril in the treatment of essential hypertension in elderly patients. Issue Section:. Download all slides. View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert. Subject alert. Any disagreements were resolved through discussion. We contacted study authors for additional information. This update contains five new trials.

We included a total of 23 RCTs 18 dihydropyridines, 4 non-dihydropyridines, 1 not specified with , participants with hypertension. All-cause mortality was not different between first-line CCBs and any other antihypertensive classes. What is the aim of this review? Background Appropriate lowering of elevated blood pressure in individuals with hypertension can reduce the amount of major complications of hypertension, such as stroke, heart attack, congestive heart failure, and even death.

Search date We collected and analysed all relevant studies up to 01 September Key results There was no difference in deaths from all causes between CCBs and other blood pressure-lowering medications. Quality of the evidence We assessed the quality of the evidence as mostly moderate, although more trials are desirable. Authors' conclusions:. Search strategy:.